The collection of paintings spans five centuries of art history: Flemish and Italian masters from the 15th to the 19th century, several oils from the two sons of Pieter Bruegel, as well as from Henri Fantin-Latour and James Ensor. To represent the 20th century, the Van Buurens selected artists such as Paul Signac, Léonard Foujita, Max Ernst, Georges Braque, and for the Belgian school, Constant Permeke, Rik Wouters, Gustave De Smet, etc.
The sculptures in the Van Buuren collection include works by André Willequet, Georges Minne, the Martel brothers and Dolf Ledel. Alice Van Buuren exhibited the works of young sculptors, thereby continuing her work as a patron of the arts.
The décor, carefully designed by the most renowned artists and interior designers of the time, is a masterful illustration of what Art Deco did best.
A remarkable feature of the house is the pride of place afforded to the furniture and objects for and around which the residence was built. David and Alice Van Buuren bought many works before the house was even completed.